Welcome to the Placeboxx

Placebo Response Prediction Tool for Osteoarthritis Intra-Articular Injection Trials

This tool is developed based on a model-based meta-analysis (MBMA), aiming to help researchers and clinicians predict placebo responses in patients with osteoarthritis (OA) receiving intra-articular injections.

By entering key clinical variables (e.g., baseline symptom severity, type of placebo, target joints, BMI) and a time point, you can quickly obtain the typical placebo response values at that time point for the following outcomes: WOMAC pain, VAS pain, WOMAC stiffness, WOMAC function, WOMAC total.

To ensure reliable predictions, the model defines a reasonable range for each input variable. Accurate predictions are only guaranteed when the input values fall within the range covered by existing studies.

This tool provides a standardized reference for clinical trial design and clinical decision-making.

WOMAC Pain

E_wp — Placebo response for WOMAC pain (change from baseline)
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VAS Pain

E_vp — Placebo response for VAS pain (change from baseline)
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WOMAC Stiffness

E_ws — Placebo response for WOMAC stiffness (change from baseline)
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WOMAC Function

E_wf — Placebo response for WOMAC function (change from baseline)
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WOMAC Total

E_wt — Placebo response for WOMAC total (change from baseline)
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Placeboxx — Model-Based Meta-Analysis Prediction Tool